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This South Korean cohort study of 424444 people found that regular aspirin use was associated with a 9% decrease in all-cause mortality over the 5-year follow-up period. The beneficial effects were seen in the 40 - 60 year old age group only, whereas no benefit was seen in the over 60 year old group. Comment: This study found that the benefit was due to a reduction in cancer deaths, not in mortality from cardiovascular disease. The authors do not speculate why the benefit was not seen in those over 60 years of age, only saying that the long-term use of aspirin in the elderly remains controversial. The full article is located here: http://10.3349/ymj.2020.61.12.997 Yonsei Med J . 2020 Dec;61(12):997-1003.    (retrieved Dec, 2020). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.