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Low dose aspirin appears to significantly inhibit the COX enzyme in skeletal muscle and significantly reduce production of PGE2. Comment: The effect of chronically reduced PGE2 in skeletal muscle is not well known but possibly beneficial in maintaining muscle mass into old age. More studies are needed. J Appl Physiol (1985) . 2020 Oct 1.    (retrieved Oct, 2020). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.