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Heart rate variability was found to be decreased (indicating a higher cardiovascular risk) in patients with major depressive disorder, which was worse if anxiety was also present. PLoS One. 2012;7(2):e30777    (retrieved Jun, 2012). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.