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This observational study of 653 patients with COPD exacerbation found that point-of-care c-reactive protein (CRP) testing helped decrease the use of antibiotics, without worse clinical outcomes at 2 week follow-up. Comment: Recommended CRP cutoff levels were: < 20 mg/L antibiotics not recommended, 20 to 40 possibly helpful, over 40 likely helpful. N Engl J Med. 2019 Jul 11;381(2):111-120.    (retrieved Jul, 2019). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.