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In patients at high risk for gastrointestinal ulcer, adding esomeprazole to a daily aspirin (used to reduce cardiovascular risk) appears to reduce risk of an ulcer, and this benefit appears to outweigh the risks of long term proton pump inhibitor use. Vasc Health Risk Manag. 2013;9:245-54. doi: 10.2147/VHRM.S44265    (retrieved Apr, 2014). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.