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This observation study of 29 685 women who had been on bisphosphonate therapy for 5 years identified 507 incident hip fractures (1.7%). Continuing therapy for an additional 2 to 5 years did not lower fracture risk. Comment: This study suggests no benefit, and possible harm, of continuing treatment for osteoporosis with bisphosphonates beyond 5 years of treatment. JAMA Netw Open . 2020 Dec 1;3(12):e2025190.    (retrieved Dec, 2020). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.