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This meta-analysis concludes that in diabetics at increased cardiovascular risk who are already on metformin, the addition of specific GLP-1 RAs and SGLT-2 inhibitors have a favorable effect on certain cardiovascular outcomes. Comment: There are lots of nuances in these recommendations which the authors go over in detail. It is worth reading the full article. Ann Intern Med . 2020 Jun 30. doi: 10.7326/M20-0864.    (retrieved Jun, 2020). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.