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In painful diabetic neuropathy, duloxetine and amitriptyline have similar efficacy. Good, moderate, and mild pain relief was achieved in about 55%, 20%, and 10% of patients, respectively. Dry mouth was significantly more common in the amitriptyline group. Patients preferred duloxetine over amitriptyline, however, this difference was not statistically significant. Diabetes Care. 2011 April; 34(4): 818�822.    (retrieved May, 2012). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.