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In patients with non-valvular atrial fibrillation, there appears to be no or little benefit of aspirin therapy in addition to coumadin therapy. Dual antiplatelet and anticoagulant therapy increases major bleeding risk. Comment: There may be a role for dual antiplatelet / anticoagulant therapy in patients with non-valvular atrial fibrillation who are within 12 months of acute coronary syndrome or revascularization. However, with these exclusions in place, the researchers still found that 45% of the patients in their retrospective review were receiving both an anticoagulant and aspirin. J Thromb Thrombolysis. 2016 Sep 24;    (retrieved Sep, 2016). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.