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Consumption of over 450 IU a day of vitamin D compared to under 300 IU a day was associated with a lower risk of early-onset colorectal cancer in women. Comment: Of note, although the authors state that the major source of vitamin D is sunlight exposure, they did not control for skin color (which affects response to sun exposure) and did not measure serum vitamin D levels but only used a predictive model. This study is suggestive but certainly not definitive. Gastroenterology . 2021 Jul 7;S0016-5085(21)03235-2.    (retrieved Aug, 2021). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.