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This meta-analysis found that when using high dose NSAIDS, naproxen may be the preferred agent because of a lower risk of vascular complications (myocardial infarction, stroke, vascular death). All high dose NSAIDS approximately doubled the risk of heart failure. Some consider naproxen the preferred agent when long-term high-dose NSAID therapy is used in patients at increased risk of cardiovascular disease (uptodate.com 2014). Lancet. 2013 Aug 31;382(9894):769-79.    (retrieved Feb, 2014). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.