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Negative experiences on Facebook are significantly associated with depressive symptoms. Comment: The cause and effect in this situation are not known, however, negative interactions on Facebook definitely appear to be a red flag for depression. J Adolesc Health. 2016 Aug 18    (retrieved Aug, 2016). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.