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In early bereavement, cardiovascular risk is increased. In this study, metoprolol at 25 mg a day and aspirin at 100 mg a day was found to reduce physiological and psychological surrogate measures of cardiovascular risk. Comment: This study found that low dose metoprolol plus aspirin decreased cardiovascular risk factors, but was not designed to determine if there was an actual change in adverse cardiovascular events. Am Heart J. 2019 Nov 13;220:264-272    (retrieved Jan, 2020). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.