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This study of 730 225 individuals found that HCTZ is better tolerated than chlorthalidone in terms of cardiovascular disease outcomes. Furthermore, it was more likely to cause electrolyte disturbances and kidney problems. Comment: This study suggests there is no benefit to chlorthalidone over HCTZ. JAMA Intern Med . 2020 Apr 1;180(4):542-551.    (retrieved Nov, 2020). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.