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This study of 4742 patients with heart failure with a reduced ejection fraction, adding dapagliflozin to standard therapy improved clinical outcomes in both diabetics and non-diabetics. Comment: This is an important study in that it finds that a diabetic medication, dapagliflozin, is helpful in both diabetics and non-diabetics (as determined by A1c levels) with HFrEF. Note that the dapagliflozin was added to conventional therapy, not substituted. Is it possible that dapagliflozin would be even more beneficial if it was an early treatment, rather than just an add-on to standard therapy? JAMA . 2020 Apr 14;323(14):1353-1368.    (retrieved Oct, 2020). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.