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Tramadol hydrochloride 37.5 mg with acetaminophen 325 mg has been shown to be most effective in patients with mild to moderate pain and has a lower risk of serious adverse events. The combination appears more effective than tramadol alone. Drugs Today (Barc). 2011 Oct;47(10):763-72.    (retrieved May, 2012). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.