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Aspirin and clopidogrel combination therapy reduced risk of a second stroke during the first 3 months after the initial stroke. The reduction was greater than for either agent alone within the first 3 months. However, use of combination therapy at beyond one year after the initial stroke did not decrease the risk of a second stroke but did increase risk of bleeding. Cerebrovasc Dis. 2014 Dec 24;39(1):13-22.    (retrieved Dec, 2014). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.