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In higher risk critically ill patients, gastric prophylaxis with proton pump inhibitors or H2 blockers likely result in important reductions in gastrointestinal bleeding but increased risk of pneumonia. Overall, this review concluded that there was no important effect on in-hospital morbidity or mortality. BMJ. 2020 Jan 6;368:l6744    (retrieved Jan, 2020). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.