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Beta blockers do not seem to be helpful in the secondary prevention after stroke or TIA. Comment: This systematic review looked at only 2 randomized controlled trials involving 2193 participants. Is it really reasonable to do a meta-analysis on just 2 studies? Cochrane Database Syst Rev. 2014 Oct 15;10:CD007890.    (retrieved Oct, 2014). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.