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This review paper addresses the various uses of melatonin, a powerful lipophilic antioxidant. Supplementation has shown potential benefits in a wide range of conditions from bone health to cardiovascular disease. Proper dosing remains unknown. Comment: This is an excellent, in-depth open access review of melatonin. There remains a lot to learn. At this point, it appears to be the safest treatment for insomnia with possible important side benefits. The effect of long-term supplementation isn't know. Antioxidants (Basel) . 2020 Nov 5;9(11):E1088.    (retrieved Nov, 2020). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.