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Guaifenesin was found in this study to have no measurable effect on sputum volume or properties. The authors conclude that it is unlikely to be an expectorant or mucolytic when used to treat acute respiratory tract infections. Comment: In other words, it is unlikely to be of any benefit at all in respiratory tract infections. Respir Care. 2014 May;59(5):631-6. doi: 10.4187/respcare.02640    (retrieved Mar, 2020). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.