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This Swedish case registry study looked at 24786 peole with colorectal cancer who were randomly matched to 74358 controls. Researchers found that aspirin reduced colorectal cancer by about 9%; that selective serotonin reuptake inhibitor (SSRI) use decreased colorectal cancer by about 7%; and that those on both aspirin and an SSRI had about a 23% reduced risk of colorectal cancer. Comment: This is a novel finding worth investigating further but the association isn't clear. For example SSRI medications have been shown to be associated with a lower rate of bladder cancer (https://doi.org/10.3390/cancers12051184), but another study showed no benefit of SSRIs in colorectal cancer (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072592/). Am J Gastroenterol . 2021 Feb 26.    (retrieved Mar, 2021). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.