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Alternative acute and preventive agents should always be explored since opioids do not work well clinically in migraine. Headache. 2012 May;52 Suppl 1:30-4.    (retrieved May, 2012). There are currently 1090 pearls in the database. While every attempt has been made to ensure accuracy, mistakes can and do occur. Use databank at your own risk. All pearls © 2024 by the Internet Medical Association. Click Here to view more medical pearls.